Paper of the Month - January, 2011

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Systematic review and meta-analysis of the tolerability and hepatotoxicity of antifungals in empirical and definitive therapy for invasive fungal infection

Wang JL, Chang CH, Young-Xu Y et al.
In this meta-analysis, the authors evaluated the hepatotoxicity of antifungal agents in the treatment of invasive fungal infections, and examined whether hepatotoxicity was the cause of treatment discontinuation and study withdrawal. The risk of hepatotoxicity was higher in patients with aspergillosis compared with those with candidiasis. Voriconazole, itraconazole, and amphotericin B formulations were the antifungal agents associated with the highest risks of hepatotoxicity.


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