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Diagnosis and Assessment

Bergeron A, Belle A, Sulahian A et al.  Chest 2010;137:410–5.

In this study, galactomannan (GM) assay was performed on bronchoalveolar lavage (BAL) fluid from patients with hematological malignancies and pulmonary infiltrates. Thirty-three patients were diagnosed with invasive pulmonary aspergillosis, of whom 19 had a positive result on GM assay of BAL fluid. The test had a sensitivity of 58% and a specificity of 96% at a cut-off optical density index of 0.5.


The diagnosis of invasive pulmonary aspergillosis (IPA) is often difficult to make with the currently available microbiological and pathological tools. The use of markers such as galactomannan (GM) to improve IPA diagnosis has therefore received much attention. Recently, GM detection in bronchoalveolar lavage (BAL) fluid has been found to be a promising alternative to detecting GM in serum [1]. The present authors sought to determine the contribution that the detection of GM in BAL fluid has to the diagnosis of IPA in patients with hematological disorders.

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