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Michallet M, Sobh M, Morisset S et al. Med Mycol 2011;49:681–7.

In this study, the effect of posaconazole prophylaxis on the incidence of invasive aspergillosis (IA) and short- and long-term mortality rate in patients with acute myeloid leukemia was assessed. Older age and no response to treatment were associated with the development of IA. Posaconazole prophylaxis resulted in decreased mortality rates at day 100, although it appears that the benefit might disappear at long-term follow-up.


Acute myeloid leukemia (AML) is an important risk factor for invasive aspergillosis (IA), and increasingly more patients are being placed on antifungal prophylaxis. Prophylaxis with posaconazole has been shown to reduce mortality rates related to invasive fungal infections (IFIs) in patients with AML [1]. The purpose of this study was to determine the outcome of patients with AML who received posaconazole prophylaxis and to describe the risk factors predisposing to IA in this patient population.

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