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Volume 4 Issue 1

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IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

Sereti I, Dunham RM, Spritzler J et al.; ACTG 5214 Study Team.
Blood 2009;113:6304–14. In this randomized, placebo-controlled, dose-ranging clinical trial of single-dose subcutaneous injection of interleukin-7 administered to 11 patients with HIV on highly active antiretroviral therapy, the investigators found few adverse events and a potentially favorable increase in circulating CD4+ and CD8+ cells of central memory phenotype.
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